Early Returns on Small Molecule Therapeutics for SARS-CoV-2
Mark Namchuk
Abstract
The COVID-19 pandemic has generated an unprecedented response within the scientific community. Extraordinary efforts have been undertaken to identify potential new therapeutics to treat SARS-CoV-2 infection spanning traditional medicinal chemistry, repurposing, and computational approaches. The breadth of the effort and rapid progression of many small molecules to clinical testing provide an opportunity to determine what chemical and testing approaches have been the most efficient in identifying potential treatments and how this may inform preparation for future pandemics.
Topics & Concepts
RepurposingPandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)2019-20 coronavirus outbreakDrug repositioningSmall moleculeData scienceComputational biologyMedicineComputer scienceBiologyVirologyPharmacologyInfectious disease (medical specialty)DiseaseDrugOutbreakEcologyGeneticsPathologySARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesComputational Drug Discovery Methods