Vitamin D Receptor Controls Cell Stemness in Acute Myeloid Leukemia and in Normal Bone Marrow
Étienne Paubelle, Florence Zylbersztejn, Thiago Trovati Maciel, Caroline Carvalho, Annalisa Mupo, Meyling Cheok, Liesbet Lieben, Pierre Sujobert, Justine Decroocq, Akihiko Yokoyama, Vahid Asnafi, Elizabeth Macintyre, Jérôme Tamburini, Valérie Bardet, Sylvie Castaigné, Claude Preudhomme, Hervé Dombret, Geert Carmeliet, Didier Bouscary, Yelena Ginzburg, Hughes de Thé, Marc Benhamou, Renato C. Monteiro, George S. Vassiliou, Olivier Hermine, Ivan Cruz Moura
Abstract
cells, and demethylating agents induce VDR expression. Association of VDR agonists with hypomethylating agents promotes leukemia stem cell exhaustion and decreases tumor burden in AML mouse models. Thus, Vdr functions as a regulator of stem cell homeostasis and leukemic propagation.
Topics & Concepts
Bone marrowMyeloid leukemiaCancer researchLeukemiaStem cellReceptorMyeloidMyeloid cellsMedicineVitaminBiologyInternal medicineCell biologyAcute Myeloid Leukemia ResearchRetinoids in leukemia and cellular processesNeuroblastoma Research and Treatments