A low-dose combination of ketamine and guanosine counteracts corticosterone-induced depressive-like behavior and hippocampal synaptic impairments via mTORC1 signaling
Anderson Camargo, Ana Paula Dalmagro, Ingrid A.V. Wolin, Aline Siteneski, Ana Lúcia Bertarello Zeni, Ana Lúcia S. Rodrigues
Topics & Concepts
mTORC1KetamineEndocrinologyInternal medicineSynapsin IGuanosineCyclic guanosine monophosphateCorticosteroneAntidepressantHippocampusPharmacologyPrefrontal cortexMedicineHippocampal formationPI3K/AKT/mTOR pathwayChemistrySignal transductionAnesthesiaPsychiatryNitric oxideBiochemistryCognitionHormoneSynaptic vesicleVesicleMembraneTryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol