Vascular smooth muscle cell-derived hydrogen sulfide promotes atherosclerotic plaque stability via TFEB (transcription factor EB)-mediated autophagy
Zhenzhen Chen, Chenxi Ouyang, Haizeng Zhang, Yuanrui Gu, Yue Deng, Congkuo Du, Changting Cui, Shuangyue Li, Wenjie Wang, Wei Kong, Jingzhou Chen, Jun Cai, Bin Geng
Abstract
S: hydrogen sulfide; LAMP1: lysosomal associated membrane protein 1; LAPTM5: lysosomal protein transmembrane 5; NaHS: sodium hydrosulfide hydrate; ox-LDL: oxidized-low density lipoprotein; PPG: DL- propagylglycine; TFEB: transcription factor EB; 3-MA: 3-methyladenine; VSMCs: vascular smooth muscle cells.
Topics & Concepts
AutophagyTFEBVascular smooth muscleCell biologyBiologyCystathionine gamma-lyaseApoptosisCancer researchCystathionine beta synthaseChemistryBiochemistryEndocrinologyEnzymeCysteineSmooth muscleSulfur Compounds in BiologyAdvanced Glycation End Products researchCholesterol and Lipid Metabolism