Small-molecule targeting PKM2 provides a molecular basis of lactylation-dependent fibroblast-like synoviocytes proliferation inhibition against rheumatoid arthritis
Yan-Hang Wang, Peng Gao, Yuqi Wang, Luzheng Xu, Ke‐Wu Zeng, Pengfei Tu
Topics & Concepts
PKM2ArthritisPharmacologyCancer researchRheumatoid arthritisCell growthCell cycleFibroblastIn vivoMedicineChemistryCell biologyCellImmunologyPyruvate kinaseBiologyGlycolysisIn vitroInternal medicineBiochemistryMetabolismBiotechnologyBiochemical and Molecular ResearchRheumatoid Arthritis Research and TherapiesQuinazolinone synthesis and applications