Central nervous system involvement by severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2)
Alberto Paniz‐Mondolfi, Clare Bryce, Zachary Grimes, Ronald E. Gordon, Jason Reidy, John A. Lednicky, Emilia Mia Sordillo, Mary Fowkes
Abstract
Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS-CoV-2.
Topics & Concepts
CoronavirusRespiratory systemCentral nervous systemVirusVirologyMedicineSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Severe acute respiratory syndromeCoronaviridaeImmunologyCoronavirus disease 2019 (COVID-19)PathologyInternal medicineDiseaseInfectious disease (medical specialty)Long-Term Effects of COVID-19SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies