Monitoring of cancer ferroptosis with [<sup>18</sup>F]hGTS13, a system xc- specific radiotracer
Abraham S. Moses, R.S. Malek, Mustafa Tansel Kendırlı, Pierre Cheung, Madeleine Landry, Marco Herrera‐Barrera, Abbas Khojasteh, Monica Granucci, S. Bukhari, Jody E. Hooper, Melanie Hayden Gephart, Scott J. Dixon, Lawrence D. Recht, Corinne Beinat
Abstract
F]hGTS13 represents a promising tool to distinguish cell types that demonstrate sensitivity or resistance to ferroptosis-inducing therapies that target system xc-, and monitor the engagement of these drugs.
Topics & Concepts
CancerRadiochemistryChemistryMedicineInternal medicineFerroptosis and cancer prognosisRNA modifications and cancerCancer, Lipids, and Metabolism