Toward Enantiomerically Pure β-Seleno-α-amino Acids via Stereoselective <i>Se</i>-Michael Additions to Chiral Dehydroalanines
Paula Oroz, Claudio D. Navo, Alberto Avenoza, Jesús H. Busto, Francisco Corzana, Gonzalo Jiménez‐Osés, Jesús M. Peregrina
Abstract
-Michael additions provide an excellent channel for the synthesis of enantiomerically pure selenocysteine (Sec) derivatives, which pose high potential for chemical biology applications.
Topics & Concepts
DiselenideMichael reactionDehydroalanineSelenocysteineStereoselectivityNucleophileConjugateChemistrySeleniumDiphenyl diselenideBicyclic moleculeCatalysisOrganic chemistryCombinatorial chemistryStereochemistryAmino acidCysteineMathematicsBiochemistryEnzymeMathematical analysisOrganoselenium and organotellurium chemistryChemical Synthesis and AnalysisEnzyme Catalysis and Immobilization