NFκB pathway dysregulation due to reduced RelB expression leads to severe autoimmune disorders and declining immunity
Nigel Sharfe, Ilan Dalal, Zahra Naghdi, Diane Lefaudeux, Linda Vong, Harjit Dadi, Héctor I. Navarro, Diana Tasher, Adi Ovadia, Tzili Zangen, Dorit Ater, Bo Ngan, Alexander Hoffmann, Chaim M. Roifman
Topics & Concepts
RELBCommon variable immunodeficiencyImmune dysregulationImmunologyAutoimmunityImmune systemExome sequencingPrimary immunodeficiencyDownregulation and upregulationCancer researchImmunodeficiencyTranscription factorBiologyCIITALoss functionMedicineGeneticsT cellNFKB1MutationPhenotypeMHC class IIGeneAntibodyNF-κB Signaling PathwaysImmune Response and InflammationCell death mechanisms and regulation