Serum exosomal long noncoding RNAs lnc-FAM72D-3 and lnc-EPC1-4 as diagnostic biomarkers for hepatocellular carcinoma
Zhicheng Yao, Changchang Jia, Yan Tai, Hao Liang, Zhaozhong Zhong, Zhiyong Xiong, Meihai Deng, Qi Zhang
Abstract
overexpression inhibited cell proliferation and induced cell apoptosis, indicating that it functions as a tumor suppressor gene. Collectively, these findings show that lnc-FAM72D-3 and lnc-EPC1-4 play a novel role that might contribute to hepatocarcinogenesis and identify potential candidate biomarkers for HCC diagnosis.
Topics & Concepts
Long non-coding RNAGene knockdownOncogeneBiologyViability assayCancer researchHepatocellular carcinomaCell growthApoptosisCellSmall nucleolar RNAMALAT1microRNACell cycleDownregulation and upregulationGeneBiochemistryGeneticsCancer-related molecular mechanisms researchCircular RNAs in diseasesExtracellular vesicles in disease