First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours
Debbie Robbrecht, Christiane Jungels, Morten Mau‐Sørensen, Iben Spanggaard, Ferry A.L.M. Eskens, Signe Øien Fretland, Tormod Kyrre Guren, Philippe Aftimos, David Liberg, Christer Svedman, Lars Thorsson, Neeltje Steeghs, Ahmad Awada
Topics & Concepts
MedicineNauseaPharmacodynamicsPharmacokineticsAdverse effectVomitingInternal medicineGastroenterologyAntibodyToxicityImmune systemPharmacologyImmunologyInflammasome and immune disordersImmune Response and InflammationToxin Mechanisms and Immunotoxins