Combined DNA Methylation and Gastric Microbiome Marker Predicts <i>Helicobacter pylori</i>-Negative Gastric Cancer
Min-Jeong Kim, Han‐Na Kim, Jonathan P. Jacobs, Hyo‐Joon Yang
Abstract
Background/Aims: -negative GC. Methods: -negative patients, including chronic gastritis (CG), intestinal metaplasia (IM), and GC. A combined analysis of DNA methylation and gastric microbiome, using 16S rRNA gene sequencing, was performed in 30 of 75 patients. Results: -negative GC after adjusting for age, sex, and atrophy (OR, 50.00; 95% CI, 1.69 to 1,476; p=0.024). Conclusions: -negative GC.
Topics & Concepts
Helicobacter pyloriMedicineDNA methylationCancerMicrobiomeMethylationHelicobacter InfectionsDNACancer researchGastroenterologyBioinformaticsInternal medicineGeneticsBiologyGeneGene expressionHelicobacter pylori-related gastroenterology studiesGastric Cancer Management and OutcomesGastrointestinal disorders and treatments