Stem Cells Treatment for Wilson Disease
Sujun Zheng, Shan Tang, Li Bai, Zhongping Duan
Abstract
Wilson Disease (WD) is a copper excretion disorder, mainly caused by mutations in the ATP7B gene. Pharmacological therapies and liver transplantation are currently the main treatment methods for WD, but they face problems such as drug treatment compliance, adverse reactions, and shortage of liver donors. Stem cell therapy of WD may correct abnormal copper metabolism permanently, which is the focus of current research. In this review, we summarized the latest research on stem cells treatment for WD, as well as current challenges and future expectations.
Topics & Concepts
Stem cellDiseaseWilson's diseaseBiologyMedicineCell biologyPathologyTrace Elements in HealthHeavy Metal Exposure and ToxicityAluminum toxicity and tolerance in plants and animals