Preparation of new chiral diene ligands and their use in the rhodium catalyzed asymmetric annulation of 2-formylarylboronic acid with dialkylalkynes
Yu Sun, Yuanmeng Li, Xiuqi Wang, Xu Cao, Hong‐Ping Deng, Xiaoli Bu, Mengtao Ma, Fei Xue
Abstract
Herein, we report the rhodium-catalyzed domino arylation/cyclization reaction of unactivated internal alkynes to afford the optically active indenols in excellent yields (up to 92%) and extremely high enantioselectivities (up to 99% ee) in the presence of new amide substituted chiral diene ligands. Notably, a total of 21 new chiral diene ligands are synthesized, which are potential choices for other asymmetric reactions.
Topics & Concepts
DieneRhodiumChemistryAnnulationAmideCatalysisDominoOptically activeCombinatorial chemistryOrganic chemistryNatural rubberCatalytic C–H Functionalization MethodsCatalytic Alkyne ReactionsCatalytic Cross-Coupling Reactions