A novel theranostic activity-based probe targeting kallikrein 7 for the diagnosis and treatment of skin diseases
Evangelos Bisyris, Eleni Zingkou, Golfo G. Kordopati, Minos–Timotheos Matsoukas, Plato Α. Magriotis, Georgios Pampalakis, Georgia Sotiropoulou
Abstract
Enzyme specific inhibitors can be designed based on endogenous substrate peptide motifs and modified to yield specific activity-based probes (ABPs). The development/validation of a theranostic ABP-inhibitor prototype for KLK7 protease is presented.
Topics & Concepts
KallikreinProteasePeptideSubstrate (aquarium)EndogenyChemistryEnzymeYield (engineering)NanotechnologyCombinatorial chemistryBiochemistryMaterials scienceBiologyMetallurgyEcologyCoagulation, Bradykinin, Polyphosphates, and AngioedemaPhytochemical compounds biological activitiesMonoclonal and Polyclonal Antibodies Research