Label-free, non-contact, in vivo ophthalmic imaging using photoacoustic remote sensing microscopy
Zohreh Hosseinaee, Layla Khalili, James A. Tummon Simmons, Kevan Bell, Parsin Haji Reza
Abstract
We present, to the best of our knowledge, the first label-free, non-contact, in vivo imaging of the ocular vasculature using photoacoustic remote sensing (PARS) microscopy. Both anterior and posterior segments of a mouse eye were imaged. Vasculature of the iris, sclera, and retina tissues were clearly resolved. To the best of our knowledge, this is the first study showing non-contact photoacoustic imaging conducted on in vivo ocular tissue. We believe that PARS microscopy has the potential to advance the diagnosis and treatment of ocular diseases.
Topics & Concepts
ScleraIn vivoPhotoacoustic imaging in biomedicineIRIS (biosensor)MicroscopyBiomedical engineeringPreclinical imagingMedicineRetinaMaterials sciencePathologyOphthalmologyOpticsBiologyComputer scienceNeuroscienceComputer visionBiotechnologyPhysicsBiometricsPhotoacoustic and Ultrasonic ImagingOptical Coherence Tomography ApplicationsThermography and Photoacoustic Techniques