Tranexamic acid for safer surgery: the time is now
Michael P. W. Grocott, Mike Murphy, Ian Roberts, Rob Sayers, Cheng‐Hock Toh
Abstract
Tranexamic acid reduces surgical bleeding. Consistent with previous research, the POISE-3 (Peri-Operative Ischemic Evaluation-3) trial found that tranexamic acid reduces major bleeding by 25% and with a low probability of any increase in thromboembolic events. Wider tranexamic acid use will improve surgical safety, avoid unnecessary blood use, reduce the risk of transfusion transmitted infections, and save healthcare funds. 'Consideration of tranexamic acid use' should be included in the safe surgery checklist. We have the evidence, and we need to act on it.
Topics & Concepts
Tranexamic acidChecklistMedicineSAFERAnesthesiaBlood transfusionSurgeryBlood lossComputer sciencePsychologyCognitive psychologyComputer securityBlood transfusion and managementTrauma, Hemostasis, Coagulopathy, ResuscitationVenous Thromboembolism Diagnosis and Management