Recent Approaches to Targeting Canonical NFκB Signaling in the Early Inflammatory Response to Renal IRI
Shelby Reid, James W. Scholey
Abstract
Ischemia reperfusion injury (IRI) is the most common cause of in-hospital AKI and is associated with increased morbidity and mortality. IRI is associated with an early phase of inflammation primarily regulated by the canonical NF κ B signaling pathway. Despite recent advances in our understanding of the pathogenesis of IRI, few therapeutic strategies have emerged. The purpose of this manuscript is to review interventions targeting NF κ B after IRI.
Topics & Concepts
MedicinePathogenesisInflammationNF-κBNon canonicalAcute kidney injurySignal transductionBioinformaticsImmunologyInternal medicineBiologyCell biologyAcute Kidney Injury ResearchNeutrophil, Myeloperoxidase and Oxidative MechanismsRNA regulation and disease