Rapid changes in transcriptomic profile and mitochondrial function in human soleus muscle after 3-day dry immersion
Daniil V. Popov, Pavel A. Makhnovskii, В. Г. Згода, Guzel R. Gazizova, Tatiana F. Vepkhvadze, Egor M. Lednev, Evgeniia Motanova, Е. А. Лысенко, О. И. Орлов, Elena Tomilovskaya
Abstract
Three-day dry immersion (a model of physical unloading) substantially changes the transcriptomic profile in the human soleus muscle, a muscle with predominantly slow-twitch fibers and strong postural function; despite this, we found no effect on the muscle proteome (highly abundant proteins). Dry immersion markedly reduces ADP-stimulated respiration; this decline is not accompanied by a decrease in the content of mitochondrial proteins/respiratory enzymes, indicating the disruption in regulation of cellular respiration.
Topics & Concepts
TranscriptomeProteomeCitrate synthaseCell biologyGlycolysisSoleus muscleBiologyMitochondrionProteomicsChemistryBiochemistrySkeletal muscleGene expressionMetabolismEndocrinologyGeneEnzymeMuscle Physiology and DisordersExercise and Physiological ResponsesCardiovascular and exercise physiology