C<sub>28</sub> Terpenoids from Lamiaceous Plant <i>Perovskia scrophulariifolia</i>: Their Structures and Anti-neuroinflammatory Activity
Naonobu Tanaka, Kanji Niwa, Seita Kajihara, Daisuke Tsuji, Kohji Itoh, Nilufar Z. Mamadalieva, Yoshiki Kashiwada
Abstract
Structurally unique C28 terpenoids, perovsfolins A (1) and B (2), were isolated from the aerial parts of an Uzbek medicinal plant, Perovskia scrophulariifolia (Lamiaceae). Their chemical structures including an unprecedented 6/8/6/6/6 pentacyclic carbon skeleton with a C6–C3 ester moiety were elucidated on the basis of spectroscopic analyses aided by density functional theory calculations as well as chemical evidence. Perovsfolin B (2) exhibited an anti-neuroinflammatory activity.
Topics & Concepts
TerpenoidChemistryUzbekLamiaceaeCarbon skeletonMoietyStereochemistryDensity functional theoryChemical structureOrganic chemistryTraditional medicineComputational chemistryLinguisticsMedicinePhilosophyPhytochemistry and Biological ActivitiesTraditional Chinese Medicine AnalysisNatural product bioactivities and synthesis