Activities of Quinoxaline, Nitroquinoxaline, and [1,2,4]Triazolo[4,3-a]quinoxaline Analogs of MMV007204 against Schistosoma mansoni
Stefan L. Debbert, Mikaela J. Hintz, Christian J. Bell, Kenya R. Earl, Grant E. Forsythe, Cécile Häberli, Jennifer Keiser
Abstract
The reliance on one drug, praziquantel, to treat the parasitic disease schistosomiasis in millions of people a year shows the need to further develop a pipeline of new drugs to treat this disease. Recently, an antimalarial quinoxaline derivative (MMV007204) from the Medicines for Malaria Venture (MMV) Malaria Box demonstrated promise against Schistosoma mansoni .
Topics & Concepts
PraziquantelQuinoxalineSchistosoma mansoniSchistosomiasisMalariaBiologyPharmacologyVirologyImmunologyHelminthsChemistryOrganic chemistrySynthesis and Biological EvaluationTrypanosoma species research and implicationsResearch on Leishmaniasis Studies