Relationship between Vancomycin Trough Serum Concentrations and Clinical Outcomes in Children: a Systematic Review and Meta-Analysis
Lu Cao, Zhuo Li, Peng Zhang, Suyun Yong
Abstract
To systematically evaluate the relationships between vancomycin trough serum concentrations and clinical outcomes in children using meta-analysis. Several databases, including PubMed, Elsevier, Web of Science, EMBASE, Medline, clinicaltrials.gov , the Cochrane Library, and three Chinese databases (Wanfang Data, China National Knowledge Infrastructure, and SINOMED), were comprehensively searched to obtain research articles on vancomycin use in children from inception through December 2021.
Topics & Concepts
MedicineVancomycinNephrotoxicityMeta-analysisCochrane LibraryInternal medicineOtotoxicityTrough ConcentrationSubgroup analysisMEDLINEGastroenterologyPharmacokineticsStaphylococcus aureusToxicityChemotherapyBiologyLawPolitical scienceGeneticsBacteriaCisplatinAntimicrobial Resistance in StaphylococcusStreptococcal Infections and TreatmentsBacterial Identification and Susceptibility Testing