Mitochondrial sites of contact with the nucleus
Michelangelo Campanella, Brindha Kannan
Abstract
Membrane contact sites (MCS) between mitochondria and the nucleus have been recently described. Termed nucleus associated mitochondria (NAM), they prime the expression of genes required for cellular resistance to stressors, thus offering a tethering mechanism for homeostatic communication. Here, we discuss the composition of NAM and their physiological and pathological significance.
Topics & Concepts
NucleusMitochondrionCell biologyMechanism (biology)BiologyNeurosciencePhysicsQuantum mechanicsMitochondrial Function and PathologyMetabolism and Genetic DisordersATP Synthase and ATPases Research