Short-term salicylate treatment improves microvascular endothelium-dependent dilation in young adults with major depressive disorder
Jody L. Greaney, Erika F.H. Saunders, Lacy M. Alexander
Abstract
Our data indicate that short-term treatment with therapeutic doses of the nuclear factor-κB (NF-κB) inhibitor salsalate improved nitric oxide (NO)-mediated endothelium-dependent dilation in adults with major depressive disorder (MDD). In adults with MDD, acute localized scavenging of reactive oxygen species (ROS) with apocynin improved NO-dependent dilation before, but not after, salsalate administration. These data suggest that activation of NF-κB, in part via stimulation of vascular ROS production, contributes to blunted NO-mediated endothelium-dependent dilation in young adults with MDD.
Topics & Concepts
Dilation (metric space)EndotheliumMedicineTerm (time)CardiologyInternal medicineMathematicsQuantum mechanicsCombinatoricsPhysicsCardiac Health and Mental HealthTryptophan and brain disordersStress Responses and Cortisol