Structure-based design, synthesis and antiproliferative action of new quinazoline-4-one/chalcone hybrids as EGFR inhibitors
Mohamed Hisham, Heba A. Hassan, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Alaa M. Hayallah, Mohamed Abdel‐Aziz
Topics & Concepts
ChemistryChalconeQuinazolineEGFR inhibitorsActive siteCytochrome cIn vitroEnzymeApoptosisBiochemistryEpidermal growth factor receptorPharmacologyStereochemistryReceptorMedicineQuinazolinone synthesis and applicationsSynthesis and biological activityCancer therapeutics and mechanisms