Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases
Alaa Alhayek, Ahmed S. Abdelsamie, Esther Schönauer, Virgyl Camberlein, Evelyn Hutterer, Gernot Posselt, Jamil Serwanja, Constantin Blöchl, Christian G. Huber, Jörg Haupenthal, Hans Brandstetter, Silja Weßler, Anna K. H. Hirsch
Abstract
larvae. The hydroxamates were also tested in a similar manner; they did not have an effect in infection models. This might be due to their fast binding kinetics to bacterial collagenases.
Topics & Concepts
CollagenaseChemistryBacillus cereusMicrobiologyRepurposingProteasesIn vitroStaphylococcus aureusPharmacologyBiochemistryEnzymeBiologyBacteriaGeneticsEcologyBiochemical and Molecular ResearchHemophilia Treatment and ResearchCancer-related gene regulation