Discovery of cinnamamide-barbiturate hybrids as a novel class of Nrf2 activator against myocardial ischemia/reperfusion injury
Bo Wei, Ji Zhang, Nannan Li, Longhua Yang, Xue-Li Xu, Yangyang Shi, Shaohui Liu, Yajing Chen
Topics & Concepts
ChemistryOxidative stressActivator (genetics)PharmacologyReperfusion injuryKEAP1AntioxidantIntracellularIn vivoOxidative phosphorylationBiochemistryReactive oxygen speciesIschemiaTranscription factorReceptorGeneBiologyMedicineInternal medicineBiotechnologyGenomics, phytochemicals, and oxidative stress