Mesoionic N-heterocyclic olefin catalysed reductive functionalization of CO<sub>2</sub> for consecutive <i>N</i>-methylation of amines
Subir Maji, Arpan Das, Swadhin K. Mandal
Abstract
-methylation of primary amines. Moreover, this method was utilized for the synthesis of two commercially available drug molecules. A detailed mechanistic cycle was proposed by performing a series of control reactions along with the successful characterisation of active catalytic intermediates either by single-crystal X-ray study or by NMR spectroscopic studies in association with DFT calculations.
Topics & Concepts
MesoionicOlefin fiberSurface modificationChemistryMethylationCombinatorial chemistryOrganic chemistryMedicinal chemistryCatalysisBiochemistryGenePhysical chemistryCarbon dioxide utilization in catalysisAsymmetric Hydrogenation and CatalysisCO2 Reduction Techniques and Catalysts