Application of HepG2/C3A liver spheroids as a model system for genotoxicity studies
Nicholas J. Coltman, Brandon Coke, Kyriaki Chatzi, Emma L. Shepherd, Patricia F. Lalor, Timothy Schulz-Utermoehl, Nikolas J. Hodges
Topics & Concepts
GenotoxicityDownregulation and upregulationDNA damageSpheroidCYP1A2Comet assayChemistryCarcinogenMolecular biologyXenobioticIn vitroBiologyGeneDNACytochrome P450BiochemistryToxicityEnzymeOrganic chemistry3D Printing in Biomedical ResearchLiver physiology and pathologyPluripotent Stem Cells Research