Role of extracellular vesicles in intercellular communication during reproduction
Kasun Godakumara, Keerthie Dissanayake, Mohammad Mehedi Hasan, Suranga P. Kodithuwakku, Alireza Fazeli
Abstract
The mammalian reproduction is a process of controlled cellular growth and development regulated by constant communication between the gametes, the subsequent embryo and the maternal system. Extracellular vesicles (EVs) are involved in these communications to a significant degree from the gamete production and maturation to fertilization, embryo development and implantation. They regulate the cellular physiology and the immune reaction to bring about a favourable environment for a successful pregnancy. Deciphering the mechanisms employed in EV-mediated embryo maternal communication could improve our knowledge in mammalian reproduction and increase the efficiency of animal breeding.