Microwave-Assisted Synthesis of Schiff Bases of Isoniazid and Evaluation of Their Anti-Proliferative and Antibacterial Activities
Bayan Ahed Al-Hiyari, Ashok K. Shakya, Rajashri R. Naik, Sanaa K. Bardaweel
Abstract
Three new Schiff bases of isoniazid were synthesized using microwave-assisted synthesis and conventional condensation with aromatic aldehydes. Synthesized compounds were characterized using elemental analysis, IR, NMR, and Mass spectroscopy. Synthesized compounds were evaluated for antiproliferative activity against MCF-7 cell line. The IC50 values were from 125 to 276 µM. The compounds were also evaluated for antibacterial activity against Staphylococcus aureus and Escherichia coli. Results showed that the synthesized compounds produce significant antibacterial activity in vitro. Inhibition of compounds ranged from 13 to 18 mm.
Topics & Concepts
ChemistryAntibacterial activityIsoniazidSchiff baseStaphylococcus aureusElemental analysisNuclear chemistryProton NMREscherichia coliOrganic chemistryStereochemistryBacteriaBiochemistryTuberculosisBiologyGeneticsMedicineGenePathologySynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsMetal complexes synthesis and properties