A Tead1-Apelin axis directs paracrine communication from myogenic to endothelial cells in skeletal muscle
Umji Lee, Pascal Stuelsatz, Sonia Karaz, David W. McKellar, Julie Russeil, Mária Deák, Iwijn De Vlaminck, Christoph Lepper, Bart Deplancke, Benjamin D. Cosgrove, Jérôme N. Feige
Abstract
, Apln peptide supplementation enhances endothelial cell expansion while Tead1 muscle overexpression delays endothelial remodeling following muscle injury. Our work describes a novel paracrine crosstalk in which Apln secretion is controlled by Tead1 in myogenic cells and influences endothelial remodeling during muscle repair.
Topics & Concepts
Paracrine signallingCell biologySkeletal muscleChemistryBiologyEndocrinologyBiochemistryReceptorApelin-related biomedical researchCardiovascular, Neuropeptides, and Oxidative Stress Research