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Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals

Camila Pulido, Timothy A. Ryan

2021Science Advances121 citationsDOIOpen Access PDF

Abstract

The cost of not thinking: unused synapses are metabolically expensive due to persistent activity of a synaptic vesicle proton pump.

Topics & Concepts

Synaptic vesicleVesicleNeuroscienceChemistryBiologyBiochemistryMembraneNeuroscience and Neuropharmacology ResearchCellular transport and secretionMitochondrial Function and Pathology
Synaptic vesicle pools are a major hidden resting metabolic burden of nerve terminals | Litcius