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Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects

Az Alddien Natfji, D. O. Nikitin, И. И. Семина, Rouslan I. Moustafine, Vitaliy V. Khutoryanskiy, Hong Lin, Gary J. Stephens, Kimberly A. Watson, Helen M. I. Osborn, Francesca Greco

2020Journal of Controlled Release12 citationsDOI

Topics & Concepts

HaloperidolCatalepsyConjugateChemistryPharmacologyIn vivoPEG ratioBlood–brain barrierReceptorBiophysicsBiochemistryDopamineEndocrinologyBiologyCentral nervous systemEconomicsBiotechnologyMathematical analysisMathematicsFinanceReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyNeuroscience and Neuropharmacology Research
Conjugation of haloperidol to PEG allows peripheral localisation of haloperidol and eliminates CNS extrapyramidal effects | Litcius