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Synthesis, biological evaluation and kinase profiling of novel S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole derivatives as cytotoxic agents with apoptosis-inducing activity

Ahmed H. Abdelazeem, Alaa M. Alqahtani, Hany A. Omar, Syed Nasir Abbas Bukhari, Ahmed M. Gouda

2020Journal of Molecular Structure30 citationsDOI

Topics & Concepts

ChemistryCytotoxicityCytotoxic T cellKinaseApoptosisMoietyLead compoundIC50StereochemistryCancer cellCell cultureCaspase 7Structure–activity relationshipGrowth inhibitionBiochemistryCaspaseIn vitroCancerProgrammed cell deathInternal medicineGeneticsBiologyMedicineSynthesis and biological activityClick Chemistry and ApplicationsSynthesis and Characterization of Heterocyclic Compounds
Synthesis, biological evaluation and kinase profiling of novel S-benzo[4,5]thiazolo[2,3-c][1,2,4]triazole derivatives as cytotoxic agents with apoptosis-inducing activity | Litcius