Macrocyclic RGD-peptides with high selectivity for α <sub>v</sub> β <sub>3</sub> integrin in cancer imaging and therapy
Xiaozhong Cheng, Chen Li, Haofei Hong, Zhifang Zhou, Zhimeng Wu
Abstract
. Additionally, the optimized cyclic peptide was functionalized with a fluorescent dye (Cy5) and the cytotoxic drug monomethyl auristatin E (MMAE), enhancing its potential for cancer imaging and targeted therapy. This work contributes a novel platform for developing integrin-targeted diagnostics and therapeutics, highlighting the importance of macrocyclic peptides in cancer treatment strategies.
Topics & Concepts
IntegrinMetastasisCancer researchReceptorCancer therapyCell adhesionAdhesionChemistryCancerCellCell biologyMedicineInternal medicineBiologyBiochemistryOrganic chemistryCell Adhesion Molecules ResearchNeuropeptides and Animal PhysiologyPlatelet Disorders and Treatments