<scp>l</scp>-Carnitine pretreatment ameliorates heat stress-induced acute kidney injury by restoring mitochondrial function of tubular cells
Hiroyasu Goto, Hiroyuki Nakashima, Kazuma Mori, Keiko Tanoue, Seigo Ito, Bradley M. Kearney, Azusa Kato, Masahiro Nakashima, Toshihiko Imakiire, Hiroo Kumagai, Manabu Kinoshita, Naoki Oshima
Abstract
Enhancing fatty acid oxidation (FAO) after acute kidney injury (AKI) improves renal outcomes. This report shows that carnitine insufficiency, which could inhibit FAO, correlates to severe heat-related illness and AKI in a clinical study. We also demonstrate that administering l-carnitine to mice improves mitochondrial respiratory function and prevents deleterious changes in renal macrophage, resulting in improved renal outcomes of heat-induced AKI. l-Carnitine may be an effective preventive treatment for severe heat-related illness and related AKI.
Topics & Concepts
Acute kidney injuryCarnitineMitochondrionFunction (biology)Heat stressOxidative stressKidneyCell biologyChemistryMedicineEndocrinologyBiologyInternal medicineAnimal scienceThermal Regulation in MedicineMetabolism and Genetic DisordersMetabolomics and Mass Spectrometry Studies