Synthesis of novel dual target inhibitors of PARP and EGFR and their antitumor activities in triple negative breast cancers
Shanshan Lin, Xiaozhen Zhang, Zelei Yu, Xiuwang Huang, Jianhua Xu, Yang Liu, Lixian Wu
Topics & Concepts
Poly ADP ribose polymeraseTriple-negative breast cancerChemistryOlaparibPARP inhibitorCancer researchEGFR inhibitorsEnzymeBreast cancerPolymeraseEpidermal growth factor receptorCancerReceptorBiologyBiochemistryMedicineInternal medicinePARP inhibition in cancer therapyDNA Repair MechanismsToxin Mechanisms and Immunotoxins