Therapeutic potential of targeting SHP2 in human developmental disorders and cancers
Dadong Shen, Wenxia Chen, Jinlin Zhu, Guofeng Wu, Runpu Shen, Meiyang Xi, Haopeng Sun
Topics & Concepts
PTPN11Allosteric regulationProtein tyrosine phosphataseProto-oncogene tyrosine-protein kinase SrcChemistryMAPK/ERK pathwaySignal transductionCancer researchPhosphataseKinaseCell biologyPhosphorylationBiologyBiochemistryEnzymeMutationKRASGeneProtein Tyrosine PhosphatasesGalectins and Cancer BiologyBioactive Compounds and Antitumor Agents