Glutamine in suppression of lipopolysaccharide-induced piglet intestinal inflammation: The crosstalk between AMPK activation and mitochondrial function
Liuqin He, Xihong Zhou, Ziping Wu, Yanzhong Feng, Di Liu, Tiejun Li, Yulong Yin
Abstract
< 0.05) the number of mitochondria and mitochondrial membrane potential. The activity of AMPK was elevated by 70% to 300% in Gln-treated IPEC-J2 cells under LPS challenge or normal conditions. Our results indicate that pre-administration of Gln to piglets suppresses intestinal inflammation by modulating the crosstalk between AMPK activation and mitochondrial function.
Topics & Concepts
Internal medicineEndocrinologyLipopolysaccharideGlutamineAMPKTumor necrosis factor alphaInflammationBiologyApoptosisProtein kinase AKinaseMedicineBiochemistryAmino acidClinical Nutrition and GastroenterologyImmune Cell Function and InteractionDiet and metabolism studies