MON-2, a Golgi protein, mediates autophagy-dependent longevity in <i>Caenorhabditis elegans</i>
Yoonji Jung, Murat Artan, Nari Kim, Jeonghun Yeom, Ara B. Hwang, Dae‐Eun Jeong, Özlem Altıntaş, Keunhee Seo, Mihwa Seo, Dongyeop Lee, Wooseon Hwang, Yujin Lee, Jooyeon Sohn, Eun Ji E. Kim, Sungeun Ju, Seong Kyu Han, Hyun-Jun Nam, Linnea M Adams, Youngjae Ryu, Dong Jin Moon, Chanhee Kang, Joo‐Yeon Yoo, Sang Ki Park, Chang Man Ha, Malene Hansen, Sanguk Kim, Cheolju Lee, Seung‐Yeol Park, Seung‐Jae Lee
Abstract
. Consistently, we showed that mammalian MON2 activated GABARAPL2 through physical interaction, which increased autophagic flux in mammalian cells. Thus, the evolutionarily conserved role of MON2 in trafficking between the Golgi and endosome is an integral part of autophagy-mediated longevity.
Topics & Concepts
AutophagyLongevityCaenorhabditis elegansGolgi apparatusCell biologyEndosomeBiologyMitochondrionGeneticsApoptosisGeneEndoplasmic reticulumIntracellularGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyAlzheimer's disease research and treatments