Repurposing levomilnacipran to attenuate premature ovarian insufficiency induced by cyclophosphamide in female Wistar albino rats through modulation of TLR4/p38-MAPK/NF-κB p65, caspase-3-driven apoptosis, and Klotho protein expression
Remon Roshdy Rofaeil, Ehab E Sharata, Mina Ezzat Attya, Amira M. Abo‐Youssef, Ramadan A.M. Hemeida, Marwa M. Khalaf
Topics & Concepts
KlothoApoptosisTLR4p38 mitogen-activated protein kinasesCancer researchMAPK/ERK pathwayEndocrinologyInternal medicineMedicineChemistryCell biologyBiologyKidneySignal transductionInflammationBiochemistryReproductive Biology and FertilityChemotherapy-induced organ toxicity mitigationOvarian function and disorders