Asymmetric Synthesis of P-Stereogenic Secondary Phosphine Oxides (SPOs)
David S. Glueck
Abstract
Abstract P-Stereogenic secondary phosphine oxides [SPOs, RR′P(O)H], valuable ligands for metal complexes in asymmetric catalysis, are also building blocks for other chiral phosphorus derivatives. This short review summarizes methods used for asymmetric synthesis of P-stereogenic SPOs. 1 Introduction 2 Configurational Stability of P-Stereogenic SPOs 3 Classical Resolution, HPLC Separation, and Dynamic Resolution 4 Synthesis via Chiral Auxiliaries 5 Kinetic Resolution 6 Conclusions and Outlook
Topics & Concepts
StereocenterChemistryKinetic resolutionPhosphineResolution (logic)Enantioselective synthesisStereochemistryCatalysisCombinatorial chemistryOrganic chemistryArtificial intelligenceComputer scienceAsymmetric Hydrogenation and CatalysisSynthetic Organic Chemistry MethodsAsymmetric Synthesis and Catalysis