Indolylarylsulfones bearing phenylboronic acid and phenylboronate ester functionalities as potent HIV‑1 non-nucleoside reverse transcriptase inhibitors
Shujing Xu, Shu Song, Lin Sun, Ping Gao, Shenghua Gao, Yue Ma, Dongwei Kang, Yusen Cheng, Xujie Zhang, Srinivasulu Cherukupalli, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Topics & Concepts
ChemistryIndole testReverse transcriptaseEC50Nucleoside Reverse Transcriptase InhibitorBoronic acidPhenylboronic acidStereochemistryNucleosideReverse-transcriptase inhibitorCarboxamideMutantCombinatorial chemistryIn vitroBiochemistryRNAGeneCatalysisHIV/AIDS drug development and treatmentHIV Research and TreatmentPneumocystis jirovecii pneumonia detection and treatment