Rational engineering of a functional CpG-free ITR for AAV gene therapy
Xiufang Pan, Yongping Yue, Maria Boftsi, Lakmini P. Wasala, Ngoc Tam Tran, Keqing Zhang, David J. Pintel, Phillip W.L. Tai, Dongsheng Duan
Topics & Concepts
CpG siteTransduction (biophysics)BiologyViral vectorVector (molecular biology)Genetic enhancementMolecular biologyGeneVirologyCell biologyComputational biologyGeneticsRecombinant DNAGene expressionBiophysicsDNA methylationVirus-based gene therapy researchCRISPR and Genetic EngineeringRNA Interference and Gene Delivery