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New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring

Eric Goffin, Pierre Fraikin, Dayana Abboud, Pascal De Tullio, Caroline Beaufour, Iuliana Botez, Julien Hanson, Laurence Danober, Pierre Francotte, Bernard Pirotte

2023European Journal of Medicinal Chemistry14 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryAMPA receptorBenzothiadiazineAllosteric regulationStereochemistryAllosteric modulatorPharmacologyNMDA receptorSubstituentReceptorBiochemistryMedicinal chemistryMedicineSynthesis and Biological EvaluationPhenothiazines and Benzothiazines Synthesis and ActivitiesStructural and Chemical Analysis of Organic and Inorganic Compounds
New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring | Litcius