Positive end-expiratory pressure affects geometry and function of the human diaphragm
Diana Jansen, Annemijn H. Jonkman, Heder de Vries, Myrte Wennen, Judith Elshof, Maud A. Hoofs, Marloes van den Berg, A. Man, Christiaan Keijzer, Gert‐Jan Scheffer, Johannes G. van der Hoeven, Armand R. J. Girbes, Pieter R. Tuinman, J. Tim Marcus, Coen A. C. Ottenheijm, Leo Heunks
Abstract
We demonstrate that PEEP causes changes in diaphragm geometry, especially muscle shortening, and decreases in vivo diaphragm contractile function. Thus, prerequisites for the development of diaphragm longitudinal muscle atrophy are present with the acute application of PEEP. Once confirmed in ventilated critically ill patients, this could provide a new mechanism for ventilator-induced diaphragm dysfunction and ventilator weaning failure in the intensive care unit (ICU).