Radical relay strategy for the construction of alkylsulfonated indolo[2,1-<i>a</i>]isoquinoline-6(5<i>H</i>)-ones <i>via</i> SO<sub>2</sub> insertion/Smiles rearrangement
Si‐Wei Tian, Long‐Jin Zhong, Jian‐Hong Fan, Kewen Tang, Yu Liu
Abstract
insertion to obtain alkylsulfonyl radical species, which avoids the use of unstable alkyl sulfonyl chlorides and highly toxic sulfonyl hydrazides. Additionally, this method for the direct assembly of alkylsulfonated polycyclic molecule skeletons displays high chemical selectivity, broad substrate scope, and step-economy.
Topics & Concepts
IsoquinolineSmiles rearrangementIntramolecular forceRelayChemistryStereochemistryMedicinal chemistryCombinatorial chemistryPhysicsPower (physics)Quantum mechanicsSulfur-Based Synthesis TechniquesPhenothiazines and Benzothiazines Synthesis and ActivitiesCatalytic C–H Functionalization Methods