A combined experimental and computational study of NHC-catalyzed allylation of allenoate with MBH esters: new regiospecific and stereoselective access to 1,5-enyne
Fang Sun, Fangfang Lu, Xue Song, Wenchao Wu, Kai Zhang, Chenxia Yu, Tuanjie Li, Donghui Wei, Changsheng Yao
Abstract
An NHC-catalyzed regiospecific allylation of α-substituted allenoates with MBH carbonates derived from aryl aldehyde furnished highly functionalized 1,5-enynes.
Topics & Concepts
ChemistryStereoselectivityEnyneAldehydeCatalysisArylOrganic chemistryMedicinal chemistryCombinatorial chemistryAlkylN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions