Synergistic Effect of the Combination of Deferoxamine and Fluconazole <i>In Vitro</i> and <i>In Vivo</i> against Fluconazole-Resistant <i>Candida</i> Spp.
Lulu An, Jingwen Tan, Yuanyuan Wang, Siyu Liu, Yongyong Li, Lianjuan Yang
Abstract
The opportunistic fungal infections are an increasing threat to humans due to the increasing number of patients with immunodeficiency, in which the most popular fungal pathogen is Candida albicans . Fluconazole (FLC) is the common drug for treating C. albicans infections, but increasing drug resistance has limited its clinical use.
Topics & Concepts
FluconazoleIn vivoIn vitroMicrobiologyDeferoxaminePharmacologyBiologyAntifungalMedicineChemistryBiochemistryBiotechnologyAntifungal resistance and susceptibilityPneumocystis jirovecii pneumonia detection and treatmentFungal Infections and Studies